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SOX11兔單克隆抗體

SOX11兔單克隆抗體

  • 價格￥1000
  • 規(guī)格100ul
  • 貨號HKZ150188
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150188SOX11兔單克隆抗體100ul支1000
SOX11
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50065?Clone# ?BP6070
Predicted?Molecular Wt:
47kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P35716
Background:
SOX11?(SOX = SRY-related?HMG?box)?is a?nuclear transcription factor?belonging to?subgroup?C?of?SRY?(sex?determining?region?on Y-chromosome)?related?HMG?(high?mobility group)?box genes.?It contains 2?functional?domains: A?HMG?box?DNA-binding??domain,?located at the?N-terminus, and a transactivation?domain?(TAD),?located?at?the?C-terminus.
SOX11 expression?is critical for embryonic?neurogenesis and?tissue?remodeling,?it?is?normally?expressed?during?the?developing?nervous system of?human?embryos and?is?required for?neurite growth?and?neuron?survival.?Expression?is?seen?in fetal?tissues????(18-25 weeks)?mainly?in?the?brain. Outside?the?CNS?SOX11?seems?primarily?to?be?expressed?at?sites?of?epithelial-mesenchymal interactions. SOX11?is?not expressed?in?normal adult?human tissues,?and?its?over-expression?is?reported?in?over?90%?of?mantle?cell?lymphomas?(MCL),?including the?rare cyclin?D1?negative cases.
Currently the only diagnostic application?is verification?of?mantle?cell?lymphomas,?particularly the?rare?cyclin?D1?negative?cases.
Subcellular?location:Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:Synthetic?peptide corresponding to SOX11?residues
within?aa300-400 of??SOX11?was?used?as?an immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Chen?Y-H?etal.?Mod.?Pathol. 2010;23(1):105–12.
2. ?Mozos?A?et?al.?Haematologica.?2009;94(11):1555–1562.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections analysis?of
mantle?zone cell
lymphoma tissue
labelling?SOX11?with
BP6070.?Heat?mediated antigen?retrieval?was
performed?using
Tris/EDTA?buffer?pH?9.0

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