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- 價格￥600
- 規(guī)格100ul
- 貨號HKZ150390
- 單位支
- 品牌HaoKebio
產(chǎn)品介紹
產(chǎn)品參數(shù)
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| 品牌 | 商品編碼 | 商品名稱 | 規(guī)格 | 單位 | 單價 |
|---|
| HaoKebio | HKZ150390 | AFP兔單克隆抗體 | 100ul | 支 | 600 |
|---|
AFP
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50267?Clone# ?BP6244
Predicted?Molecular Wt:
67kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P02771
Background:
Alpha-fetoprotein?(AFP)?is a?65?kDa glycoprotein found?in the?mammalian fetal?liver, yolksac, and?GI?tract.?While?AFP
expression?in?adult cells?is?low,?it?is aberrantly expressed?in?adult?liver cancer?cells.?The?tumor?suppressor?gene?p53?and?β-?????catenin are?both?involved?in the?regulation?of AFP expression.?In?normal?adult?cells,?p53?binds to?the?repressor?region?of the?AFP gene, thereby?blocking transcription.?Mutations?in?both?p53 and?β-catenin are associated?with?aberrant?expression?of????AFP.?Research studies?have shown that elevated serum?AFP?levels?are?predictive?of?hepatocellular?carcinoma.
AFP?is?not expressed?in?adult?liver tissue,?but?it?is aberrantly expressed?in?adult?liver?cancer?cells.?AFP?is?mainly?used?in clinical diagnosis of?hepatocellular carcinoma.
Subcellular?location:
Cytoplasmic
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?Meier, V. et?al.?(2006) Comp?Hepatol?5,?2.
2. ?Peng, S.Y. et?al.?(2004)?Int?J?Cancer?112,?44-50.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
embedded?sections)?analysis of ?hepatocellular?carcinoma?labelling?AFP?with?BP6244.?
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