CD146兔單克隆抗體

價(jià)格￥1000
規(guī)格100ul
貨號(hào)HKZ150307
單位支
品牌HaoKebio

產(chǎn)品介紹

產(chǎn)品參數(shù)

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品牌	商品編碼	商品名稱	規(guī)格	單位	單價(jià)
HaoKebio	HKZ150307	CD146兔單克隆抗體	100ul	支	1000

CD146
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50184?Clone# ?BP6162
Predicted?Molecular Wt:
72kD
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P43121
Background:
CD146?plays a?role?in cell adhesion, and?in?cohesion?of the?endothelial?monolayer?at?intercellular junctions?in vascular?tissue.?Its?expression?may allow?melanoma cells to?interact with cellular?elements?of the?vascular?system,thereby?enhancing
hematogeneous tumor spread. Could?bean adhesion?molecule active?in?neural?crest?cells?during?embryonic?development.CD146???acts as surface?receptor that triggers tyrosine?phosphorylation of?FYN?and?PTK2/FAK1,?and?a transient?increase?in?the?intracellular?calcium concentration.
Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Shih,?I.M.?(1999) J?Pathol?189, 4-11.
2.?Wang,?P.?et?al.?(2013)?Mol?Cell?Biol?33,?3689-99.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin?embedded?sections?analysis?of?melanoma?labelling?CD146 with?BP6162.

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