CD138兔單克隆抗體

價(jià)格￥600
規(guī)格100ul
貨號(hào)HKZ150153
單位支
品牌HaoKebio

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產(chǎn)品參數(shù)

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品牌	商品編碼	商品名稱	規(guī)格	單位	單價(jià)
HaoKebio	HKZ150153	CD138兔單克隆抗體	100ul	支	600

CD138
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50030?Clone# ?BP6035
Predicted?Molecular Wt:
32kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P18827

Background:
CD138, also designated syndecan-1,?is a?member?of the?syndecan family?of four?transmembrane?spanning?proteins?capable?of?binding to?heparan sulfate and chondroitin sulfate?molecules.?The?syndecans’?main?functions?are?to?control?cell?growth?and
differentiation as well as to?maintain cell?adhesion?and?cell?migration.
?
Under?normal conditions CD138?is?predominantly expressed on?mature?plasma?cells?and?early?preB-cells,?while?other
haematolymphoid cells are?negative. Various types of epithelial?cells?are?also?CD138?positive.?Squamous?epithelial?cells?show?strong?membranous and some cytoplasmic staining,?except for the?mature?superficial?squamous?epithelial?cells?which?are
unstained.?Mature?mesenchymal and?neural tissues are?not stained. Among?haematolymphoid?neoplasms,?CD138?is?expressed?in?practically all cases of?plasma cell?malignancies. Among?nonhaematolymphoid?neoplasms?the?expression?of?CD138?is?found???in various types of carcinoma.?In the following, the?large?majority?of cases?is?CD138?positive:?skinsquamous?cell?carcinoma?and
basal cell carcinoma, colorectal adenocarcinoma,?cholangiocarcinoma, transitional?cell?carcinoma,?endometrial???adenocarcinoma, ductaland?lobular?breast carcinoma,?hepatocellular carcinoma,?renal cell?carcinoma,?and?lung?adenocarcinoma.
CD138?is a very sensitive and specific?marker?for?identification?of?plasma?cells?and?plasma?cell?differentiation?within?haematolymphoid tissues?in?benign and?neoplastic conditions.

Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to CD138?residues
within?aa200-300 of?CD138?was?used?as?an immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1. ?Nunez?AL, et.al, Am?J?Clin?Pathol.?2012?Mar;137(3):423-?8.
2.?O’Connell?FP, et.al, Am?J?Clin?Pathol.?2004?Feb;121(2):254-63.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections analysis?of
plasmacytoma tissue
labelling?CD138?with
BP6035.?Heat?mediated antigen?retrieval?was
performed?using
Tris/EDTA?buffer?pH?9.0

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