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\n![\"GADD34\u5154\u591a\u514b\u9686\u6297\u4f53\"\/](\"https:\/\/www.haokebio.com\/wp-content\/themes\/smartenterprise\/images\/loading.png\")
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![\"GADD34\u5154\u591a\u514b\u9686\u6297\u4f53\"\/](\"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/444.jpg?imageView2\/0\/format\/webp\/q\/75\")
<\/a><\/div><\/div>\nGADD34\u5154\u591a\u514b\u9686\u6297\u4f53<\/h1><\/div>
GADD34\u5154\u591a\u514b\u9686\u6297\u4f53<\/h1><\/div><\/i>\u4e00\u6297<\/a> \u6297\u4f53<\/a> \u8bd5\u5242<\/a> <\/span><\/div><\/header>- \u4ef7\u683c<\/span>\uffe51960\/\uffe52800<\/span><\/li>
- \u89c4\u683c<\/span>100ul\/200ul<\/span><\/li>
- \u8d27\u53f7<\/span>HK210150M\/HK210150L<\/span><\/li>
- \u5355\u4f4d<\/span>\u652f<\/span><\/li>
- \u54c1\u724c<\/span>HaoKebio<\/span><\/li><\/ul>\n\n\n\nQQ53383090 \u54a8\u8be2\u8d2d\u4e70<\/a><\/div>\n<\/div>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
<\/div><\/div><\/section>\n\n\n\n<\/i>\u4ea7\u54c1\u4ecb\u7ecd<\/span><\/div><\/i>\u4ea7\u54c1\u53c2\u6570<\/span><\/div><\/i>\u8d44\u6599\u4e0b\u8f7d<\/span><\/div><\/div><\/div>\n\n\u54c1\u724c<\/strong><\/span><\/th> \u5546\u54c1\u7f16\u7801<\/strong><\/span><\/th> \u5546\u54c1\u540d\u79f0<\/strong><\/span><\/th> \u89c4\u683c<\/strong><\/span><\/th> \u5355\u4f4d<\/strong><\/span><\/th> \u5355\u4ef7<\/strong><\/span><\/th><\/tr> HaoKebio<\/th> HK210150M<\/strong><\/th> GADD34\u5154\u591a\u514b\u9686\u6297\u4f53<\/strong><\/th> 100ul<\/th> \u652f<\/span><\/th> 1960<\/th><\/tr> HaoKebio<\/strong><\/td> HK210150L<\/strong><\/td> GADD34\u5154\u591a\u514b\u9686\u6297\u4f53<\/strong><\/td> 200ul<\/strong><\/td> \u652f<\/strong><\/span><\/td> 2800<\/strong><\/td><\/tr><\/tbody><\/table>
Applications<\/strong>
Tested Applications:<\/strong>
IF, IHC, WB, ELISA
Cited Applications:<\/strong>
IF, IHC, IP, WB
Species Specificity:<\/strong>
human, mouse
Cited Species:<\/strong>
hamster, human, monkey, mouse, pig, rat
Positive WB detected in:<\/strong>
K-562 cells, HepG2 cells, Tunicamycin treated HeLa cells, Jurkat cells, PC-3 cells
Positive IHC detected in:<\/strong>
human pancreas tissue, human colon cancer tissue
Note: suggested antigen retrieval with\u00a0TE buffer pH 9.0;\u00a0(*) Alternatively, antigen retrieval may be performed with\u00a0citrate buffer pH 6.0<\/em><\/strong>
Positive IF detected in:<\/strong>
PC-3 cells
Recommended dilution:<\/strong>
WB : 1:300-1:1000
IHC : 1:50-1:500
IF : 1:20-1:200
Product Information
Source:<\/strong>
Rabbit
Purification method:<\/strong>
Antigen affinity purification
Isotype:<\/strong>
IgG
Storage:<\/strong>
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20\u00b0C. Stable for one year after shipment.\u00a0Aliquoting is unnecessary for -20o<\/sup>C storage.
Immunogen Information
Full name:<\/strong>
protein phosphatase 1, regulatory (inhibitor) subunit 15A
Calculated molecular weight:<\/strong>
73 kDa
Observed molecular weight:<\/strong>
100 kDa
Gene symbol<\/strong>
PPP1R15A
Synonyms<\/strong>
GADD34, growth arrest and DNA damage-inducible protein 34, PPP1R15A
Background
GADD34, also named PPP1R15A, belongs to the PPP1R15 family. GADD34 can be triggered as a direct target of activating transcription factor4 (ATF4) under ER stress, it plays a pivotal role in the recovery of cells from shut-down of translation induced by ER stress. It recruits the serine\/threonine-protein phosphatase (PP1) to dephosphorylate the translation initiation factor eIF2alpha, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. GADD34 down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 via PP1. It may also promote apoptosis by inducing TP53 phosphorylation on \u2018Ser-15\u2019. Starvation-induced expression of GADD34 reduced mTOR activity and induced autophagy in wild-type mice, but not in GADD34 KO mice. Molecular weight of GADD34 is 100 kDa confirmed in GADD34 KO mice, and Proteintech\u2019s GADD34 antibody 10449-1-AP primarily recongize the 100 kDa band.<\/figcaption><\/figure>\n<\/div>\n\n\n\n\n<\/p>\n\n\n\n
\n\n<\/p>\n<\/div>\n<\/div>\n\n\n\n
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\n\u6682\u65e0<\/p>\n\n\n\n
\u8bf4\u660e\u6587\u6863\u4e0b\u8f7d<\/span><\/h3>- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul><\/div><\/section>\n\n\n\n
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- \u4ef7\u683c<\/span>\uffe51960\/\uffe52800<\/span><\/li>
- \u89c4\u683c<\/span>100ul\/200ul<\/span><\/li>
- \u8d27\u53f7<\/span>HK210150M\/HK210150L<\/span><\/li>
- \u5355\u4f4d<\/span>\u652f<\/span><\/li>
- \u54c1\u724c<\/span>HaoKebio<\/span><\/li><\/ul>\n\n\n\nQQ53383090 \u54a8\u8be2\u8d2d\u4e70<\/a><\/div>\n<\/div>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
<\/div><\/div><\/section>\n\n\n\n<\/i>\u4ea7\u54c1\u4ecb\u7ecd<\/span><\/div><\/i>\u4ea7\u54c1\u53c2\u6570<\/span><\/div><\/i>\u8d44\u6599\u4e0b\u8f7d<\/span><\/div><\/div><\/div>\n\n\u54c1\u724c<\/strong><\/span><\/th> \u5546\u54c1\u7f16\u7801<\/strong><\/span><\/th> \u5546\u54c1\u540d\u79f0<\/strong><\/span><\/th> \u89c4\u683c<\/strong><\/span><\/th> \u5355\u4f4d<\/strong><\/span><\/th> \u5355\u4ef7<\/strong><\/span><\/th><\/tr> HaoKebio<\/th> HK210150M<\/strong><\/th> GADD34\u5154\u591a\u514b\u9686\u6297\u4f53<\/strong><\/th> 100ul<\/th> \u652f<\/span><\/th> 1960<\/th><\/tr> HaoKebio<\/strong><\/td> HK210150L<\/strong><\/td> GADD34\u5154\u591a\u514b\u9686\u6297\u4f53<\/strong><\/td> 200ul<\/strong><\/td> \u652f<\/strong><\/span><\/td> 2800<\/strong><\/td><\/tr><\/tbody><\/table>
Applications<\/strong>
Tested Applications:<\/strong>
IF, IHC, WB, ELISA
Cited Applications:<\/strong>
IF, IHC, IP, WB
Species Specificity:<\/strong>
human, mouse
Cited Species:<\/strong>
hamster, human, monkey, mouse, pig, rat
Positive WB detected in:<\/strong>
K-562 cells, HepG2 cells, Tunicamycin treated HeLa cells, Jurkat cells, PC-3 cells
Positive IHC detected in:<\/strong>
human pancreas tissue, human colon cancer tissue
Note: suggested antigen retrieval with\u00a0TE buffer pH 9.0;\u00a0(*) Alternatively, antigen retrieval may be performed with\u00a0citrate buffer pH 6.0<\/em><\/strong>
Positive IF detected in:<\/strong>
PC-3 cells
Recommended dilution:<\/strong>
WB : 1:300-1:1000
IHC : 1:50-1:500
IF : 1:20-1:200
Product Information
Source:<\/strong>
Rabbit
Purification method:<\/strong>
Antigen affinity purification
Isotype:<\/strong>
IgG
Storage:<\/strong>
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20\u00b0C. Stable for one year after shipment.\u00a0Aliquoting is unnecessary for -20o<\/sup>C storage.
Immunogen Information
Full name:<\/strong>
protein phosphatase 1, regulatory (inhibitor) subunit 15A
Calculated molecular weight:<\/strong>
73 kDa
Observed molecular weight:<\/strong>
100 kDa
Gene symbol<\/strong>
PPP1R15A
Synonyms<\/strong>
GADD34, growth arrest and DNA damage-inducible protein 34, PPP1R15A
Background
GADD34, also named PPP1R15A, belongs to the PPP1R15 family. GADD34 can be triggered as a direct target of activating transcription factor4 (ATF4) under ER stress, it plays a pivotal role in the recovery of cells from shut-down of translation induced by ER stress. It recruits the serine\/threonine-protein phosphatase (PP1) to dephosphorylate the translation initiation factor eIF2alpha, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. GADD34 down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 via PP1. It may also promote apoptosis by inducing TP53 phosphorylation on \u2018Ser-15\u2019. Starvation-induced expression of GADD34 reduced mTOR activity and induced autophagy in wild-type mice, but not in GADD34 KO mice. Molecular weight of GADD34 is 100 kDa confirmed in GADD34 KO mice, and Proteintech\u2019s GADD34 antibody 10449-1-AP primarily recongize the 100 kDa band.<\/figcaption><\/figure>\n<\/div>\n\n\n\n\n<\/p>\n\n\n\n
\n\n<\/p>\n<\/div>\n<\/div>\n\n\n\n
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\n\u6682\u65e0<\/p>\n\n\n\n
\u8bf4\u660e\u6587\u6863\u4e0b\u8f7d<\/span><\/h3>
- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul><\/div><\/section>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>
<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":7870,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"themepark_post_bcolor":"#f5f5f5","themepark_post_width":"1022px","themepark_post_img":"","themepark_post_img_po":"left","themepark_post_img_re":false,"themepark_post_img_cover":false,"themepark_post_img_fixed":false,"themepark_post_hide_title":false,"themepark_post_main_b":"","themepark_post_main_p":100,"themepark_paddingblock":false,"footnotes":""},"categories":[101,99,98],"tags":[],"class_list":["post-10882","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yk","category-kt","category-products"],"metadata":{"_wp_page_template":["default"],"_wpcom_metas":["a:1:{s:11:\"show_indent\";s:1:\"0\";}"],"views":["1101"],"_canshu":["a:5:{i:0;a:5:{s:5:\"title\";s:6:\"\u4ef7\u683c\";s:4:\"text\";s:15:\"\uffe51960\/\uffe52800\";s:2:\"f1\";i:16;s:2:\"f2\";s:7:\"#e21f2f\";s:2:\"f3\";b:1;}i:1;a:5:{s:5:\"title\";s:6:\"\u89c4\u683c\";s:4:\"text\";s:11:\"100ul\/200ul\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:2;a:5:{s:5:\"title\";s:6:\"\u8d27\u53f7\";s:4:\"text\";s:19:\"HK210150M\/HK210150L\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:3;a:5:{s:5:\"title\";s:6:\"\u5355\u4f4d\";s:4:\"text\";s:3:\"\u652f\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";b:0;}i:4;a:5:{s:5:\"title\";s:6:\"\u54c1\u724c\";s:4:\"text\";s:8:\"HaoKebio\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}}"],"catce":["sidebar-widgets4"],"_dp_original":["10874"],"_edit_lock":["1729753761:2"],"_edit_last":["2"],"_thumbnail_id":["7870"]},"medium_url":null,"thumbnail_url":null,"full_url":null,"_links":{"self":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/10882"}],"collection":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/comments?post=10882"}],"version-history":[{"count":2,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/10882\/revisions"}],"predecessor-version":[{"id":10884,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/10882\/revisions\/10884"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/media?parent=10882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/categories?post=10882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/tags?post=10882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul>