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PTEN兔單克隆抗體

PTEN兔單克隆抗體

  • 價(jià)格￥1000
  • 規(guī)格100ul
  • 貨號HKZ150429
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150429PTEN兔單克隆抗體100ul支1000
PTEN
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50306?Clone# ?BP6283
Predicted?Molecular Wt:
54kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P60484
Background:
PTEN acts as a dual-specificity?protein?phosphatase,?dephosphorylating tyrosine-,?serine-?and?threonine-phosphorylated
proteins. Tumor suppressor, the?lipid?phosphatase activity?is critical for?its tumor?suppressor function.?Antagonizes?the?PI3K-?AKT/PKB signaling?pathway?by dephosphorylating?phosphoinositides and thereby?modulating cell?cycle?progression?and?cell??survival. The?unphosphorylated form cooperates with?MAGI2 to suppress AKT1?activation.
PTEN gene?is a tumor suppressor gene that?maps to?chromosome?10q23.?PTEN?is?the?first?oncogene?with?bispecific
phosphatase activity discovered?in?humans,?regulating tumour cell growth,?apoptosis?and?migration,?etc.?PTEN?is found?to?be??inactivated?in a variety of tumours, and?its?inactivation?is?due to?methylation?modifications?in?addition?to?common?mutations.
High-grade endometrioid carcinomas are commonly?deficient?in?PTEN?expression.
PTEN gene deletion?has also?been found?in glioblastoma,?prostate?cancer,?melanoma,?and?breast?cancer.
Subcellular?location:
Cytoplasm?，?Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Song?M.S. et?al.?Nature?455:813-817.
2.?Stohr?N. et?al.?Genes?Dev.?26:176-189
Immunohistochemical?(formalin/PFA-fixed?paraffin-?embedded?sections)?analysis of?human endometrial?carcinoma?labelled?with?PTEN?using?BP6283.

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