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p53鼠單克隆抗體

p53鼠單克隆抗體

  • 價格￥600
  • 規(guī)格100ul
  • 貨號HKZ150313
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150313p53鼠單克隆抗體100ul支600
p53
Mouse?Monoclonal Antibody?Product?Datasheet
Catalog# BX50190???Clone# ?BPM6168
Predicted?Molecular Wt:
58kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P04637
Background:
p53?has?been observed to act as?both?as?a tumor-suppressor?and?transcription?factor.?By?binding?to?DNA,?the?normal?p53
negatively?regulates cell growth?and?division.?In case of?DNA?damage,?p53?arrests the?cell?cycle?until?repair?has taken?place.?In
case?repair?is?not?possible,?p53?induces?apoptosis.?p53 acts?a?two?checkpoints?in?the?cell?cycle,?between?G1?and?S,?and between?G2 and?M,?respectively.
p53?is expressed?in the?nuclei of all?normal cells,?but?usually?not?immunohistochemically?detectable?due?to?a?very?short?half-?life?(10-20?min.).?In?tumor?tissues,?p53?is?overexpressed?in?over?50% of?human?cancers.?Positive?staining?of?p53?detected?by ??immunohistochemistry?has?been observed?in colon cancer,?breast cancer,?lung?cancer,?prostate?cancer?and?ovarian?cancer.
p53?has?been?used to differentiate?uterine serous carcinoma from?endometrioid?carcinoma,?as well?as?a?marker?for?intratubular germ cell?neoplasia.
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?human wild type?p53?protein was?used as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Wang?L??etal.?IUBMB?Life?71:45-56.
2. ?Dang?X??etal. Chem?Biol?Interact?300:82-90.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis of colon?cancer tissue?labelling
p53 with?BMP6142.?Heat mediated?antigen
retrieval was?performed????using Tris/EDTA?buffer?pH?9.0

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