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Progesterone Receptor兔單克隆抗體

Progesterone Receptor兔單克隆抗體

  • 價格￥1000
  • 規(guī)格100ul
  • 貨號HKZ150199
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150199Progesterone Receptor兔單克隆抗體100ul支1000
Progesterone?Receptor
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50076?Clone# ?BP6081
Predicted?Molecular Wt:
99kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P06401
Background:
Progesterone?is one of the central?regulators of female?reproduction.?In?breast?development,?progesterone?is?involved?in the???formation of?lobular-alveolar structures and also?affects?differentiation?in?the?breast?by?modulation?of?milk?protein?synthesis.??The cellular effects of?progesterone are?mediated through?progesterone?receptors?(PR).?PR,a?protein?with?946?amino?acids,?is?a?ligand-activated transcription factor?member of the steroid?receptor superfamily?of?nuclear?receptors.?PR?is?predominantly??expressed?in female sex steroid?responsive tissues such?as the?mammary?gland,?uterus?and?ovary?but?is?also found?in?other
tissues such as endocrine cells?of the?Langerhans’?islets.
The estrogen?receptor?(ER) and?PR status?has?been?used for?over?20 years?as?a?predictor?of?breast?carcinoma?responsiveness?to endocrine therapy and as a?prognostic?indicator?for?early?recurrence.
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein corresponding to?residues within?aa400-600 of??progesterone?receptor?was?used?as?an
immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:300-1:600
Background?References:
1. ?Bardou?V-J, ArpinoG,?Elledge?RM, et?al. J?Clin?Oncol 2003;21:1973-1979.
2.??Elledge?RM, GreenS,?Pugh?R etal.??Int J?Cancer?2000;89:111-117.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis of
breast?cancer?labelling?progesterone?receptor?with?BP6081.?Heat
mediated?antigen
retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0

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