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p63兔單克隆抗體

p63兔單克隆抗體

  • 價格￥1000
  • 規(guī)格100ul
  • 貨號HKZ150156
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150156p63兔單克隆抗體100ul支1000
p63
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
?
Catalog# ?BX50033?Clone# ?BP6038
?
Predicted?Molecular Wt:
77kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q9H3D4
Background:
p63?is a transcription factor?related to the tumor suppressor?gene?p53?and?play?acritical?role?in the?development?of?stratified??epithelia?by?maintaining?basal cell?regenerative capacity?and?perhaps?by?playing a?role?in?mediating ectodermal-mesenchymal?interactions.
In?normal tissues,?p63 expression?is?presented?in the?basal cells of?stratified?epithelia?such?as?skin,?ectocervix,?esophagus,
urothelium, and?bronchi.?p63?is also found?in?basal cells of?glandular?tissue?such?as?prostate?and?breast?and?in?lymphoid?tissue.?In tumor tissues, the?p63 gene?is amplified and the?protein?is?overexpressed?in?primary?lung?and?head?and?necksquamous?cell
carcinomas. Squamous cell carcinomas of the?larynx,?esophagus,?skin,?and?cervix?also?express?p63.?p63?expression?has?also?been?documented?in?basal cell carcinomas of skin.?However,?some studies?also?show?that?p63?expressed?in?a?subset?of
adenocarcinomas and?large cell carcinomas?of?lung.
In?diagnostic?pathology?practice,?p63?has?been studied as a?marker of?basal?cells to?help?in?the?diagnosis?of?ductal?carcinoma?in?situ of the?breast versus?invasive carcinoma?in fine-needle aspirates.?Similarly,?p63?has?been tested?as?a?marker?to?identify
basal cells?in the diagnostic work-up for?prostatic?cancer.?Recently,?some studies?have?suggested?that?p63?in?combination?with?other?markers?may?be?used to?help?in?differentiating squamous cell carcinomas from?other tumor?types?in?cases?difficult?to
diagnose?histologically.
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)
for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?p63?residues within?aa580-680 of?p63 was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Au?NH, et.al,Appl?Immunohistochem?Mol?Morphol.
2004 Sep;12(3):240-7.
2. ?Lewis?JS, et.al,?Mod?Pathol.?2005?Nov;18(11):1471-81.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections?analysis of SCC?of?lung tissue?labelling???p63 with?BP6038.?Heat ?mediated?antigen
retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0
?

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